Sodium Antimonyv Gluconate in the Treatment of Indian Kala-Azar
نویسندگان
چکیده
The preliminary results of treatment of 50 cases of kala-azar and 2 cases of post-kala-azar dermal leishmaniasis were reported by the writers (Sen Gupta and Chakravarty, 1945) last year. Of the 50 cases of kala-azar treated, two died during treatment and 48 were discharged as clinically cured. The immediate results of this trial were quite satisfactory, the immediate cure rate being about 96 per cent, but it was emphasized that unless the relapse rate had been studied, accurate evaluation of this drug in the treatment of kala-azar would not be possible. In this paper it is proposed to present the results of the following up of the cases for a period of not less than 6 months after the completion of treatment, and to discuss the value of this drug in the treatment of kala-
منابع مشابه
The Treatment of Kala-Azar with Sodium Antimony-V-Gluconate: Preliminary Observations *The work reported in this paper was undertaken under the Endowment Fund of the Calcutta School of Tropical Medicine, aided by a grant from the Indian Research Fund Association.
A pentavalent antimony compound (Sdt. 561, solustibosan, antimony-v-hexonate, containing 20 mg. of antimony per c.cm. of solution) , that made a stable solution and could be given intramuscularly, was first introduced b) Prof. H. Schmidt, the pioneer worker on pent*1' valent antimony compounds. Kikuth and Schmidt (1938) found that this compound possessed a marked curative action in the le*,' ma...
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the patient had visceral leishmaniasis (kala-azar), successfully treated with 30 intramuscular injections of sodium stibogluconate (SSG). Polymerase chain reaction showed Leishmania donovani DNA in a buffy coat specimen. Post-kala-azar dermal leishmaniasis (PKDL) is a chronic skin rash usually seen in apparently cured kala-azar patients in East Africa and South Asia. In the Indian subcontinent,...
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Pentavalent antimonials (SbV) have been successfully used for treatment of kala-azar since last six decades. Since 1970s its conventional dosages have failed to achieve with 60 per cent unresponsiveness reported with WHO regimen in Bihar (India). Pentamidine initially used as a second line of drug, acquired resistance (25%) even with prolonged dosage. Newer oral drug miltefosine is a potent ant...
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Sodium antimony gluconate (SAG) and miltefosine used in the treatment of kala-azar are known to cause several side effects but severe thrombocytopenia has not been reported. Four cases of severe thrombocytopenia, two caused by SAG and two by miltefosine were promptly detected and treated by immediate withdrawal of the offending drugs, platelet and blood transfusions and dexamethasone. After imp...
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